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Salvianolic acid B attenuates liver fibrosis by targeting Ecm1 and inhibiting hepatocyte ferroptosis.
Fu Y, Zhou X, Wang L, Fan W, Gao S, Zhang D, Ling Z, Zhang Y, Ma L, Bai F, Chen J, Sun B, Liu P. Fu Y, et al. Redox Biol. 2024 Feb;69:103029. doi: 10.1016/j.redox.2024.103029. Epub 2024 Jan 3. Redox Biol. 2024. PMID: 38184998 Free PMC article.
Erastin- or CCl(4)-induced hepatocyte ferroptosis models with or without Ecm1 gene knockdown were evaluated in vitro. Subsequently, the interaction between Ecm1 and xCT and the binding kinetics of Sal B and Ecm1 were determined. ...Mechanistically, Sal B prot …
Erastin- or CCl(4)-induced hepatocyte ferroptosis models with or without Ecm1 gene knockdown were evaluated in vitro. Subsequently, t …
Shionone Attenuates Sepsis-Induced Acute Kidney Injury by Regulating Macrophage Polarization via the ECM1/STAT5 Pathway.
Zhang B, Xue Y, Zhao J, Jiang H, Zhu J, Yin H, Qiu Y, Hu A, Xu L, Song Y, Wang X. Zhang B, et al. Front Med (Lausanne). 2022 Jan 24;8:796743. doi: 10.3389/fmed.2021.796743. eCollection 2021. Front Med (Lausanne). 2022. PMID: 35141243 Free PMC article.
BACKGROUNDS: To date, there are no specific drugs approved for the treatment of sepsis associated acute kidney injury (AKI). Shionone is a natural component with anti-inflammatory activity. ...It has been observed that Shionone inhibits the expression of ECM1 and at …
BACKGROUNDS: To date, there are no specific drugs approved for the treatment of sepsis associated acute kidney injury (AKI). Shionone …
Stromal protein Ecm1 regulates ureteric bud patterning and branching.
Paroly SS, Wang F, Spraggon L, Merregaert J, Batourina E, Tycko B, Schmidt-Ott KM, Grimmond S, Little M, Mendelsohn C. Paroly SS, et al. PLoS One. 2013 Dec 31;8(12):e84155. doi: 10.1371/journal.pone.0084155. eCollection 2013. PLoS One. 2013. PMID: 24391906 Free PMC article.
In the present study we demonstrate that autocrine retinoic acid (RA) signaling in stromal cells is critical for their survival and patterning, and show that Extracellular matrix 1, Ecm1, a gene that in humans causes irritable bowel syndrome and lipoid proteinosis, is a no …
In the present study we demonstrate that autocrine retinoic acid (RA) signaling in stromal cells is critical for their survival and patterni …
Identification and characterization of retinoic acid-responsive genes in mouse kidney development.
Takayama M, Miyatake K, Nishida E. Takayama M, et al. Genes Cells. 2014 Aug;19(8):637-49. doi: 10.1111/gtc.12163. Epub 2014 Jun 24. Genes Cells. 2014. PMID: 24962468 Free article.
Here, we have identified and characterized RA-responsive genes in mouse kidney development. Analysis of isolated embryonic kidneys cultured in the presence and absence of RA identified 33 candidates of RA-responsive genes. ...Our study thus identifies and characteri …
Here, we have identified and characterized RA-responsive genes in mouse kidney development. Analysis of isolated embryonic kidneys …
Urine inter-alpha-trypsin inhibitor family-related proteins may serve as biomarkers for disease activity of lupus.
Jiang J, Zhao J, Wang Y, Liu D, Zhang M. Jiang J, et al. J Clin Lab Anal. 2022 Sep;36(9):e24622. doi: 10.1002/jcla.24622. Epub 2022 Jul 23. J Clin Lab Anal. 2022. PMID: 35870194 Free PMC article.
The expression of ITIH2 and ECM1 in the renal damage group were also consistent with the screening results. ...CONCLUSIONS: In this exploratory study, we evaluated the expression of ITI family-related proteins in the urine of SLE and found that urine ITIH2 and ECM1 …
The expression of ITIH2 and ECM1 in the renal damage group were also consistent with the screening results. ...CONCLUSIONS: In this e …
Identification of urinary proteins potentially associated with diabetic kidney disease.
Marikanty RK, Gupta MK, Cherukuvada SV, Kompella SS, Prayaga AK, Konda S, Polisetty RV, Idris MM, Rao PV, Chandak GR, Dakshinamurty KV. Marikanty RK, et al. Indian J Nephrol. 2016 Nov-Dec;26(6):434-445. doi: 10.4103/0971-4065.176144. Indian J Nephrol. 2016. PMID: 27942176 Free PMC article.
Diabetic nephropathy (DN) is the most common cause of chronic kidney disease. Although several parameters are used to evaluate renal damage, in many instances, there is no pathological change until damage is already advanced. ...ECM1 and factor H are known to influe …
Diabetic nephropathy (DN) is the most common cause of chronic kidney disease. Although several parameters are used to evaluate renal …
KIM-1-mediated phagocytosis reduces acute injury to the kidney.
Yang L, Brooks CR, Xiao S, Sabbisetti V, Yeung MY, Hsiao LL, Ichimura T, Kuchroo V, Bonventre JV. Yang L, et al. J Clin Invest. 2015 Apr;125(4):1620-36. doi: 10.1172/JCI75417. Epub 2015 Mar 9. J Clin Invest. 2015. PMID: 25751064 Free PMC article.
Kidney injury molecule 1 (KIM-1, also known as TIM-1) is markedly upregulated in the proximal tubule after injury and is maladaptive when chronically expressed. ...Hence, KIM-1-mediated epithelial cell phagocytosis of apoptotic cells protects the kidney after acute …
Kidney injury molecule 1 (KIM-1, also known as TIM-1) is markedly upregulated in the proximal tubule after injury and is maladaptive …
A six-gene panel to label follicular adenoma, low- and high-risk follicular thyroid carcinoma.
Poma AM, Giannini R, Piaggi P, Ugolini C, Materazzi G, Miccoli P, Vitti P, Basolo F. Poma AM, et al. Endocr Connect. 2018 Jan;7(1):124-132. doi: 10.1530/EC-17-0261. Endocr Connect. 2018. PMID: 29298844 Free PMC article.
Twenty-five genes were differentially expressed (FDR <0.05) between FAs and WI-FTCs. Six of these (ECM1, RXRG, SDPR, SLC26A4, TIFF3, TIMP1) were also differently expressed among MI-FTCs and FAs or WI-FTCs and were considered to build a classification model, which was te …
Twenty-five genes were differentially expressed (FDR <0.05) between FAs and WI-FTCs. Six of these (ECM1, RXRG, SDPR, SLC26A4, TIFF …
Single-cell RNA-sequence analysis of mouse glomerular mesangial cells uncovers mesangial cell essential genes.
Lu Y, Ye Y, Yang Q, Shi S. Lu Y, et al. Kidney Int. 2017 Aug;92(2):504-513. doi: 10.1016/j.kint.2017.01.016. Epub 2017 Mar 18. Kidney Int. 2017. PMID: 28320530 Free article.
Among 58 endothelium-associated genes, 18 encode proteins that are secreted and may be directly involved in endothelial homeostasis. Importantly, 11 (Angpt2, Anxa5, Axl, Ecm1, Eng, Fn1, Mfge8, Msn, Nrp1, Serpine2, and Sparc) were upregulated, while 2 (Apoe and Fgf1) were d …
Among 58 endothelium-associated genes, 18 encode proteins that are secreted and may be directly involved in endothelial homeostasis. Importa …
13 results